Publications

Selected articles


Epidermal IL-15Rα acts as an endogenous antagonist of psoriasiform inflammation in mouse and man.

French LE, Bouchaud G, Gehrke S, Krieg C, et al.
J Exp Med. 2013; 210(10):2105-17. Impact Factor: 1.355. PMID: 24019554



The Nlrp3 inflammasome regulates acute graft-versus-host disease.

French LE, Jankovic D, Ganesan J, Bscheider M, et al.
J Exp Med. 2013; 210(10):1899-910. Impact Factor: 13.214. PMID: 23980097



Direct presentation of a melanocyte-associated antigen in peripheral lymph nodes induces cytotoxic CD8+ T cells.

French LE, Schuler P, Contassot E, Irla M, et al.
Cancer Res. 2008; 68(20):8410-8. Impact Factor: 7.7. PMID: 18922914



Resistance to FasL and TRAIL-mediated apoptosis in Sézary syndrome T-cells associated with impaired death receptor and cFLIP expression.

French LE, Contassot E, Kerl K, Roques S, et al.
Blood. 2008; 111(9):4780-7. PMID: 18314443



Extralymphatic tumors prepare draining lymph nodes to invasion via a T-cell cross-tolerance process.

French LE, Preynat-Seauve O, Contassot E, Schuler P, Piguet V, Huard B.
Cancer Res. 2007; 67(10):5009-16. Impact Factor: 8.2. PMID: 17510433



Tumor-infiltrating dendritic cells are potent antigen-presenting cells able to activate T cells and mediate tumor rejection.

French LE, Preynat-Seauve O, Schuler P, Contassot E, Beermann F, Huard B,
J Immunol. 2006; 176(1):61-7. PMID: 16365396



Impaired CD40L signaling is a cause of defective IL-12 and TNF-alpha production in Sézary syndrome: circumvention by hexameric soluble CD40L.

French LE, Huard B, Wysocka M, et al.
Blood. 2005; 105(1):219-25. Impact Factor: 10.1. PMID: 15315967



Inhibition of Toxic Epidermal Necrolysis by blockade of CD95 with Human Intravenous Immunoglobulin.

French LE, Viard I, Wehrli P, Bullani R, et al.
Science. 1998; 282(5388):490-3. Impact Factor: 24.4.  PMID: 9774279



APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth.

French LE, Hahne M, Kataoka T, Schröter M, et al.
J Exp Med. 1998; 188(6):1185-90. Impact Factor: 15.9. PMID: 9743536



Inhibition of death receptor signals by cellular FLIP.

French LE, Irmler M, Thome M, Hahne M, et al.
Nature. 1997; 388(6638):190-5. Impact Factor: 27.4. PMID: 9217161



Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape.

French LE, Hahne M, Rimoldi D, Schröter M, et al.
Science. 1996; 274(5291):1363-6. Impact Factor: 23.6. PMID: 8910274


Fas and Fas ligand in embryo’s and adult mice: ligand expression in several immune-privileged tissues and co-Expression in adult tissues characterized by apoptotic cell turnover.

French LE, Hahne M, Viard I, et al.
J Cell Biol. 1996; 133(2):335-43. PMID: 8609166


Human clusterin gene expression is confined to surviving cells during in vitro programmed cell death.

French LE, Wohlwend A, Sappino AP, Tschopp J, Schifferli JA.
J Clin Invest. 1994; 93(2):877-84. Impact Factor: 8.5. PMID: 8113419


Murine clusterin: molecular cloning and mRNA localization of a gene associated with epithelial differentiation processes during embryogenesis.

French, LE, Chonn, A, Ducrest, D, Baumann, B, Belin, D, Wohlwend, A,  Schifferli, JA.
The Journal of Cell Biology.1993; 122(5), 1119-30. Impact Factor: 11.7. PMID: 8354695


Distinct sites of production and deposition of the putative cell death marker clusterin in the human thymus.

French LE, Sappino AP, Tschopp J, Schifferli JA.
J Clin Invest. 1992; 90(5):1919-25. Impact Factor: 8.4. PMID: 1430214

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Book


Adverse Cutaneous Drug Eruptions

lf_pulication_book_adverseFrench LE, Editor.
Karger Books “Chemical Immunology and Allergology”. Vol. 97, (240 p., 43 fig., 30 in color, 34 tab., hard cover), 2012. DOI: 10.1159/isbn.978-3-8055-9971-9 www.karger.com/Book/Home/256747

Books chapters

Stevens-Johnson syndrome and toxic epidermal necrolysis.

Harr T, French LE.

(2012) Chem Immunol Allergy. 97:149-66.


Erythema Multiforme, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

French LE, Prins C.

(2012) Chapter 20, 319-333, in Dermatology, 3rd Ed., by Bolognia, Jorizzo and Schaffer. Ed.: Mosby.


Erythème polymorphe syndrome de Stevens-Johnson.

French LE, Saurat JH.

(2009) Chapitre 6.5, 317-320, dans Dermatologie et maladies sexuellement transmissibles (5e édition) par Saurat, Grosshans, Laugier et Lachapelle. Ed.: Masson.


Nécrolyse épidermique toxique (syndrome de Leyll).

French LE, Saurat JH.

(2009) Chapitre 6.6, 321-323, dans Dermatologie et maladies sexuellement transmissibles (5e edition) par Saurat, Grosshans, Laugier et Lachapelle. Ed. : Masson.


Erythema Multiforme, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

French LE, Prins C.

(2008) Chapter 21, 287-300 in Dermatology, 2nd Ed., by Bolognia, Jorizzo and Rapini. Ed.: Mosby.


Erythème polymorphe et syndrome de Stevens-Johnson.

French LE, Saurat JH.

(2004) Chapitre 6.5, 318-323, dans Dermatologie et maladies sexuellement transmissibles (4e édition) par Saurat, Grosshans, Laugier et Lachapelle. Ed.: Masson.


Techniques de biologie moléculaire utilisées pour le diagnostic des maladies cutanées.

French LE, Saurat JH.

(2004) Chapitre 1.3, 38-39, dans Dermatologie et maladies sexuellement transmissibles (4e édition) par Saurat, Grosshans, Laugier et Lachapelle. Ed.: Masson.


Toxic epidermal necrolysis.

French LE, Prins C.

(2003) Chapter 22, 323-333, in Dermatology by Bolognia, Jorizzo and Rapini. Ed.: Mosby.


Techniques de biologie moléculaire utilisées pour le diagnostic des maladies cutanées.

French LE, Saurat JH.

(1999) Chapitre 1, 26-28, dans Dermatologie et maladies sexuellement transmissibles (3e édition) par Saurat, Grosshans, Laugier et Lachapelle. Ed.: Masson.


Infection par le virus de l’hépatite C, cryoglobulinémie et glomérulonéphrite.

Schifferli JA, French LE, Tissot JD.

(1994) Actualités Néphrologiques 1994, pp 107-128. Ed.: Flammarion Médecine-Sciences.


Structure et immunopathologie de la peau

French LE, Saurat JH.
(1992) Chapitre 43,514-523, dans Allergologie par Charpin, J, et Vervloet, D. Ed.: Flammarion Médecine-Sciences.

Selected review articles

Neutrophilic dermatoses and autoinflammatory diseases with skin involvement-innate immune disorders.

Navarini AA, Satho TK, French LE.
Semin Immunopathol, 38:45-56, 2016, Impact Factor: 7.047


Adverse cutaneous drug eruptions: current understanding.

Hoetzenecker W, Nägeli M, Mehra ET, Jensen AN, Saulite I, Schmid-Grendelmeier P, Guenova E, Cozzio A, French LE.
Semin Immunopathol, 38:75-86, 2016, Impact Factor: 7.047


The inflammasome and IL-β: implications for the treatment of inflammatory diseases.

Satoh T, Otsuka A, Contassot E, French LE.
Immunotherapy, 243-54, 2015, Impact Factor: 2.440


The inflammasomes in autoinflammatory diseases with skin involvement.

Beer HD, Contassot E, French LE.
J Invest Dermatol, 134:1805-10, 2014, Impact Factor: 6.193


New insights into acne pathogenesis: propionibacterium acnes activates the inflammasome.

Contassot E, French LE.
J Invest Dermatol, 134:310-3, 2014, Impact Factor: 6.065


The inflammasomes in autoinflammatory diseases with skin involvement.

Beer HD, Contassot E, French LE.
J Invest Dermatol, 134:1805-10, 2014, Impact Factor: 6.065


Severe cutaneous adverse reactions: acute generalized exanthematous pustulosis, toxic epidermal necrolysis and Stevens-Johnson syndrome.

Harr T, French LE.
Med Clin North, 94:727-742, 2010, Impact Factor: 2.18


Toxic epidermal necrolysis and Stevens-Johnson syndrome.

Harr T, French LE.
Orphanet J Rare Dis, 5:39, 2010, Impact Factor: 5.825


Targeting apoptosis defects in cutaneous T-cell lymphoma.

Contassot E, French LE.
J Invest Dermatol, 129:1059-1061, 2009, Impact Factor: 4.829


Lymph node tumor metastases: more susceptible than primary tumors to CD8+ T-cell immune destruction.

Contassot E, Olivier Preynat-Seauve O, French LE, Huard B.
Trends Immunol, 30:569-573, 2009, Impact Factor: 9.48


Protein-based therapeutic approaches targeting death receptors.

French LE, Tschopp J.
Cell Death Differ, 10:117-123, 2003, Impact Factor: 8.0


Defective death receptor signaling as a cause of tumor immune escape.

French LE, Tschopp J.
Semin Cancer Biol, 12:51-55, 2002, Impact Factor: 5.8


Therapeutic advances in biological response modifiers in the treatment of cutaneous t-cell lymphoma.

Vittorio CC, Rook AH, French LE, Shapiro M, Lehrer MS, Junkinshopkins JM.
BioDrugs, 15:431-437, 2001, Impact Factor: 1.9


Death receptors in cutaneous biology and disease.

Wehrli P, Viard I, Bullani R, Tschopp J, French LE.
J. Invest Dermatol, 115:141-148, 2000, Impact Factor: 4.9


Inhibition of death receptor signaling by FLICE-inhibitory protein as a
mechanism for immune escape of tumors.

French LE, Tschopp J.
J Exp Med, 190:891-894, 1999, Impact Factor: 15.3


The TRAIL to selective tumor death.

French LE, Tschopp J.
Nature Medicine, 5:146-147, 1999, Impact Factor: 27.9


Thyroiditis and hepatitis: Fas on the road to disease.

French LE, Tschopp J.
Nature Medicine, 3:387-388, 1997, Impact Factor: 27.9